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  • Title: Investigations into the identity of the non-adrenergic, non-cholinergic excitatory transmitter in the smooth muscle of chicken rectum.
    Author: Meldrum LA, Burnstock G.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1985; 81(2):307-9. PubMed ID: 2410183.
    Abstract:
    ATP and substance P were examined as possible mediators of non-adrenergic, non-cholinergic excitatory transmission in chicken rectum. ATP and the non-degradable ATP analogue, alpha, beta-methylene ATP, mimicked the response to nerve stimulation. Substance P either produced a maintained contraction after a long latency or was inactive. After desensitization of the P2-purinoceptor by alpha, beta-methylene ATP, the responses to ATP and nerve stimulation were abolished, while the response to carbachol was little affected. It is concluded that ATP may be the transmitter in non-adrenergic, non-cholinergic excitatory nerves supplying the chicken rectum.
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