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  • Title: Comparison of different markers on blood lymphocytes of chronic lymphocytic leukemia.
    Author: Götze D, Fiebig H, Mansfeld HW, Mey U, Schön E, Uhle R, Ansorge S.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1985; 112(2):233-40. PubMed ID: 2410330.
    Abstract:
    Mononuclear cells (MNC) of 17 patients suffering from B chronic lymphocytic leukemia (B-CLL) were analysed by various immunological methods. The B cell nature of CLL cell was determined by classical tests (MRBC-rosette-test, immunofluorescence test for detection of membrane bound immunoglobulins). The cytochemical detection of the new T-cell marker dipeptidyl peptidase IV (DP IV) was found to be suitable for the characterization of B-CLL. The B-CLL cells showed granular pattern of alpha-naphthylacetate esterase (ANAE) reaction and binding of the monoclonal pan T antibody BL-T2. These non typical reactions for normal B lymphocytes can be used for differential diagnosis of B-CLL in combination with other reliable T cell markers. Avoiding the separation of T cells, the mixed rosette assay was used to enumerate Fc-IgG-receptor bearing T(TG) and non T cells. Both cell populations were found to be significantly elevated in MNC of B-CLL.
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