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  • Title: Enhanced doxorubicin delivery and cytotoxicity in multidrug resistant cancer cells using multifunctional magnetic nanoparticles.
    Author: Pilapong C, Keereeta Y, Munkhetkorn S, Thongtem S, Thongtem T.
    Journal: Colloids Surf B Biointerfaces; 2014 Jan 01; 113():249-53. PubMed ID: 24103503.
    Abstract:
    Carboxymethyl modified magnetic nanoparticles (CMC-MNPs) have been designed as a vehicle for drug delivery in both drug-sensitive and drug-resistant cancer cells. We have demonstrated that the CMC-MNPs were able to load doxorubicin (DOX) with a high loading efficiency while also maintaining a good colloidal stability in an aqueous solution. According to a drug release study, DOX-loaded CMC-MNPs showed that the pH-dependent drug release property had a much higher release rate in acidic pH. Compared to free DOX, the DOX-loaded CMC-MNPs showed higher DOX accumulation in drug-sensitive cancer cells and much higher accumulation in drug-resistant cancer cells. These results indicate that our nanoplatform is highly efficient as a drug delivery system in both normal cancer cells and MDR cancer cells. In addition, the DOX-loaded CMC-MNPs can also enhance cytotoxicity against drug-resistant cancer cells in comparison to free DOX. The results obtained in this research demonstrate that our nanoplatform may be a promising approach in cancer chemotherapy and for overcoming multidrug-resistant cancer cells.
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