These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Comparison of the results of ethacizin pharmacodynamics and pharmacokinetics in a single intravenous administration].
    Author: Shugushev KhKh, Gneushev ET, Smetnev AS, Kukes VG, Rozenshtraukh LV.
    Journal: Kardiologiia; 1985 Apr; 25(4):32-5. PubMed ID: 2410654.
    Abstract:
    A single intravenous injection of 30-50 mg ethacizin produces a favourable antiarrhythmic effect in 80-85% of patients with ventricular disorders of cardiac rhythm. The drug's action already begins "on the needle", reaches its peak within 3-5 minutes and lasts for 1-2 hours. A two-compartment model adequately represents ethacizin pharmacokinetics. The average ethacizin half-distribution and half-elimination periods are 4.7 and 154.4 minutes, respectively, and its clearance rate is 0.99 1/min. Therapeutic plasma concentration of the drug varies between 30-50 and 300-400 ng/ml.
    [Abstract] [Full Text] [Related] [New Search]