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  • Title: Enantio- and regioselective CuH-catalyzed hydroamination of alkenes.
    Author: Zhu S, Niljianskul N, Buchwald SL.
    Journal: J Am Chem Soc; 2013 Oct 23; 135(42):15746-9. PubMed ID: 24106781.
    Abstract:
    A highly enantio- and regioselective copper-catalyzed hydroamination reaction of alkenes has been developed using diethoxymethylsilane and esters of hydroxylamines. The process tolerates a wide variety of substituted styrenes, including trans-, cis-, and β,β-disubstituted styrenes, to yield α-branched amines. In addition, aliphatic alkenes coupled to generate exclusively the anti-Markovnikov hydroamination products.
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