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  • Title: Isolation and characterization of histamine-releasing peptides from human parotid saliva.
    Author: Sugiyama K, Suzuki Y, Furuta H.
    Journal: Life Sci; 1985 Aug 05; 37(5):475-80. PubMed ID: 2410754.
    Abstract:
    Peptides responsible for releasing histamine were purified from human parotid saliva. The amino acid composition of the peptides showed a high proportion of histidine, lysine and arginine. Molecular weights of these peptides were between 3000 and 5000 as determined by SDS-acrylamide gel electrophoresis. These peptides induced histamine release from rat-isolated mast cells accompanied with degranulation in a dose-dependent manner over the concentration range 5-50 micrograms/ml.
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