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  • Title: An immunohistochemical staining of epidermal Langerhans' cells in tinea cruris.
    Author: Emtestam L, Kaaman T, Hovmark A, Asbrink E.
    Journal: Acta Derm Venereol; 1985; 65(3):240-3. PubMed ID: 2411081.
    Abstract:
    Epidermal Langerhans' cells (LC) were investigated in fresh cryostat sections of ten biopsies from patients with mycologically proven tinea cruris, using OKT6 monoclonal antibodies and avidin-biotin-immunoperoxidase. Compared to the controls, more epidermal LC and an increased number of LC in the upper half of the epidermis were found in the sections from tinea patients. In a double staining method for both OKT6-positivity and hyphae, a tendency towards a gathering of LC and fungal elements was found. The results of this study are in agreement with the theory that epidermal LC are responsible for the antigen uptake in dermatophytosis.
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