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  • Title: Mucosubstance histochemistry of the normal mucosa and epithelial neoplasms of the large intestine.
    Author: Ono K, Katsuyama T.
    Journal: Acta Pathol Jpn; 1985 Mar; 35(2):281-97. PubMed ID: 2411106.
    Abstract:
    Histochemical properties of mucosubstances in normal mucosa and neoplasms of 100 operated cases with colonic carcinoma were investigated by using several new methods, such as paradoxical concanavalin A (con A) staining and modified PAS reactions for sialic acids. Acidity of goblet cell-type mucin (GCM) of the normal mucosa varied with the depth of the crypt, as well as with different segments of the large intestine, whereas surface coat-type mucin (SCM) mainly consisted of sulfomucin throughout the large intestine. In addition, the PAS reactivity revealing the presence of O-acetylated sialic acid and the labile class III con A reactivity were demonstrated as hallmarks characterizing the colonic GCM. In carcinoma tissues, sialomucin was more abundant than in the normal mucosa. Goblet-type tumor cells were found in 59 cases. Moreover, O-acetylated sialic acid and the labile class III con A reactivity persisted in GCM of the goblet-type tumor cells. GCM of the adjacent mucosa of the neoplasms showed a decrease in sulfomucin in 95 cases and a marked increase in the labile class III con A reactivity in 97 cases, while the histochemical properties of SCM in this region remained unchanged.
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