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  • Title: [Concentration level of latamoxef sodium (LMOX) in prostatic tissue].
    Author: Takao M, Matsuzaki S, Ao T, Nagakura K, Fujioka T, Hata M, Nakamura H, Hayakawa M.
    Journal: Hinyokika Kiyo; 1985 Mar; 31(3):539-43. PubMed ID: 2411116.
    Abstract:
    The concentration of latamoxef sodium (LMOX) in serum and prostatic tissue was evaluated. Thirty seven patients with benign prostatic hypertrophy were given 1 g LMOX intravenously prior to prostatectomy. Prostatic tissue and blood were sampled at 1, 2 or 3 hrs after administration of LMOX. The concentration of LMOX in prostatic tissue was 17.4 +/- 3.4 micrograms/g tissue, 11.1 +/- 1.3 microgram/g tissue and 8.9 +/- 1.3 microgram/g tissue 1, 2 and 3 hrs after injection, respectively (mean +/- S.E.). The penetration ratio of LMOX (concentration in tissue/in serum) to prostate was 30-45%. Therefore, the 80% MIC of LMOX is lower than 8 micrograms/ml for most gram negative bacteria, the results suggest that LMOX is very effective against prostatitis caused by these organisms.
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