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  • Title: Chronic treatment with nifedipine prevents development of hypertension and abnormal red cell Na+ transport in Dahl-S-rats.
    Author: Knorr A, De Mendonça M, Garthoff B, Morich F, Kazda S.
    Journal: Arch Int Pharmacodyn Ther; 1985 Jun; 275(2):248-58. PubMed ID: 2411236.
    Abstract:
    Transmembrane Na+ transport was measured in erythrocytes of salt resistant (DR) and salt sensitive (DS) Dahl rats, fed either a standard (0.4%) or high (0.8%) NaCl diet, or a high NaCl diet containing 300 ppm of the calcium entry blocker nifedipine. Whereas salt-loaded DS became severely hypertensive, those treated with nifedipine remained normotensive. With a low NaCl diet, total Na+ efflux and Na+ pump activity was lower in DS than in DR. Cotransport was more active in DS than in DR. After excess Na+ intake, total Na+ efflux was markedly reduced in DS, but normal in nifedipine-treated DS. Cell Na+ content was increased by 52% in salt-loaded DS, but not so in DS chronically treated with nifedipine. Na+ pump was completely suppressed in salt-loaded DS, but normal in DR and rats treated with nifedipine. These results suggest that Na+ pump inhibition might be involved in the development of Dahl rat hypertension, and that prevention of salt-induced hypertension by chronic nifedipine treatment also prevents suppression of erythrocytic Na+ pump. This suggests a casual link between its biochemical and therapeutic action.
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