These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Prediction and characterization of protein-protein interaction network in Xanthomonas oryzae pv. oryzae PXO99 A.
    Author: Guo J, Li H, Chang JW, Lei Y, Li S, Chen LL.
    Journal: Res Microbiol; 2013 Dec; 164(10):1035-44. PubMed ID: 24113387.
    Abstract:
    Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of bacterial blight disease in rice, is one of the most serious plant pathogens worldwide. In the current analysis, we constructed a protein-protein interaction network of Xoo strain PXO99(A) with two computational approaches (interolog method and domain combination method), and verified by K-Nearest Neighbors classification method. The predicted PPI network of Xoo PXO99(A) contains 36,886 interactions among 1988 proteins. KNN verification and GO annotation confirm the reliability of the network. Detailed analysis of flagellar synthesis and chemotaxis system shows that σ factors (especially σ(28), σ(54)) in Xoo PXO99(A) are very important for flagellar synthesis and motility, and transcription factors RpoA, RpoB and RpoC are hubs to connect most σ factors. Furthermore, Xoo PXO99(A) may have both cAMP and c-di-GMP signal transduction system, and the latter is especially important for this plant pathogen. This study therefore provides valuable clues to explore the pathogenicity and metabolic regulation of Xoo PXO99(A).
    [Abstract] [Full Text] [Related] [New Search]