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  • Title: [Effect of substances modifying calcium movement on the contractility of cultured cardiac cells].
    Author: Auclair MC, Vernimmen C, Lechat P.
    Journal: C R Seances Soc Biol Fil; 1985; 179(1):74-7. PubMed ID: 2411367.
    Abstract:
    Cultured cardiac cells from newborn rats were found to be sensitive to the positive or negative inotropic effect of agents capable of interfering with calcium movements. Calcium entry blockers were found specially potent, since diltiazem and nifedipine were still active at concentration of 1 X 10(-9) M. Such a bioassay system seems therefore convenient to compare the relative potency of drugs belonging to this pharmacological class.
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