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  • Title: [Fibrin pleurodesis in malignant pleural effusions].
    Author: Kreuser ED, Seifried E, Harsch U, Brass B, Schreml W, Heimpel H.
    Journal: Dtsch Med Wochenschr; 1985 Sep 06; 110(36):1365-8. PubMed ID: 2411490.
    Abstract:
    Fibrin pleurodesis was performed on 30 patients with malignant pleural effusions. A pleural catheter was inserted to empty the pleural space and effect the pleurodesis. When the pleural space was dry, 20 000 U of aprotinin were instilled intrapleurally for local fibrinolysis inhibition. 10 ml fibrinogen concentrate and 10 ml thrombin (500 U/ml) and 3000 KI U/ml aprotinin were then applied. Complete success was achieved in 19 of 27 patients, partial success in two. The results could not be evaluated in three patients. The only side-effect of the treatment was a subfebrile temperature in three of the 30 patients. Fibrin pleurodesis thus proved itself as an effective form of treatment with few side-effects (10%).
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