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  • Title: Human monoclonal IgM autoantibodies with restricted antigenic specificity for myelin express unrelated idiotypes.
    Author: Kahn SN.
    Journal: J Neurol Sci; 1985 Jul; 69(3):161-70. PubMed ID: 2411877.
    Abstract:
    Idiotype-specific polyclonal antisera were prepared against myelin-binding human IgM paraproteins with specificity for the myelin-associated glycoprotein (MAG). Eight anti-idiotypic sera (6 against one monoclonal IgM and 2 against another) were tested by gel precipitation, immunoradiometric and ELISA assays for binding to the myelin-binding IgM paraproteins from 12 patients with demyelinating peripheral neuropathy. Anti-idiotypic antibodies bound only to the MAG-specific IgM used for immunization; there was no evidence of idiotypic cross-reactivity between the different IgM paraproteins.
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