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  • Title: [Gonadotropin and alkaline phosphatase-producing gastric carcinoma with widespread metastasis to the bones].
    Author: Ohyama S, Yonemura Y, Hashimoto T, Shima Y, Sawa T, Miyazaki I.
    Journal: Gan No Rinsho; 1985 Jul; 31(8):990-6. PubMed ID: 2411970.
    Abstract:
    A case of advanced gastric carcinoma in a 47-year-old man with widespread metastasis of generalized bone and associated with high serum levels of human chorionic gonadotropin (hCG) and alkaline phosphatase (ALP) is reported. Macroscopically, the primary tumor was Borrmann type IV. Microscopically, it showed poorly differentiated adenocarcinoma. Bone metastasis, however, showed well-differentiated adenocarcinoma. These lesions did not manifest conspicuous trophoblastic differentiation. Immunohistochemical studies revealed that hCG-positive cells were observed sporadically in the primary tumor and lymph node metastasis, but remarkably in the bone metastasis. Cancer cells in the lymph nodes were positively stained by modified Burstone's ALP staining. The serum levels of hCG and ALP fluctuated with the clinical course. Therefore, the authors concluded that this gastric carcinoma produced hCG and ALP.
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