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  • Title: Antithyroid drug-induced agranulocytosis complicated by pneumococcal sepsis and upper airway obstruction.
    Author: Ishimaru N, Ohnishi H, Nishiuma T, Doukuni R, Umezawa K, Oozone S, Kuramoto E, Yoshimura S, Kinami S.
    Journal: Intern Med; 2013; 52(20):2355-9. PubMed ID: 24126400.
    Abstract:
    Streptococcus pneumoniae is a rare pathogen of sepsis in patients with antithyroid drug-induced agranulocytosis. We herein describe a case of antithyroid drug-induced agranulocytosis complicated by pneumococcal sepsis and upper airway obstruction. A 27-year-old woman who was previously prescribed methimazole for nine months presented with a four-day history of a sore throat. She nearly choked and was diagnosed with febrile agranulocytosis. She was successfully treated with intubation, intravenous antibiotics and granulocyte colony-stimulating factor. Her blood cultures yielded S. pneumoniae. Emergency airway management, treatment of sepsis and the administration of granulocyte colony-stimulating factor can improve the clinical course of antithyroid drug-induced pneumococcal sepsis in patients with airway obstruction.
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