These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of the calcium channel agonist, Bay K-8644 on human vascular smooth muscle.
    Author: Gopalakrishnan V, Park LE, Triggle CR.
    Journal: Eur J Pharmacol; 1985 Jul 31; 113(3):447-51. PubMed ID: 2412849.
    Abstract:
    Bay K-8644, a calcium channel activator, caused a dose-dependent (ED50 = 12.8 nM) elevation of tone in the human umbilical artery. The response to Bay K-8644 was dependent upon extracellular calcium (Ca2+), competitively antagonized by the channel antagonist, nifedipine, and, in addition, the sensitivity to Bay K-8644 was increased by, but not dependent upon, elevating extracellular potassium. Bay K-8644 competitively displaced, IC50 = 1.8 nM, specific [3H]nitrendipine binding to a microsome fraction derived from the umbilical artery, suggesting that the Ca2+ channel activator and the structurally related dihydropyridine antagonists bind to a single site to affect Ca2+ channel function in human vascular smooth muscle.
    [Abstract] [Full Text] [Related] [New Search]