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  • Title: Enantioselective total synthesis of (-)-limaspermidine and formal synthesis of (-)-1-acetylaspidoalbidine.
    Author: Zhang SX, Shen XL, Li ZQ, Zou LW, Wang FQ, Zhang HB, Shao ZH.
    Journal: J Org Chem; 2013 Nov 15; 78(22):11444-9. PubMed ID: 24131444.
    Abstract:
    Evolution of the synthetic strategy that culminated in the first asymmetric total synthesis of the Aspidosperma alkaloid limaspermidine is described. The successful enantioselective route to (-)-limaspermidine proceeds in 10 steps and with the isolation of only six intermediates using a Pd-catalyzed enantioselective decarboxylative allylation we have recently developed. This first enantioselective synthesis of (-)-limaspermidine establishes unambiguously its absolute configuration and allows the first asymmetric formal total synthesis of the Aspidoalbine alkaloid (-)-1-acetylaspidoalbidine.
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