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  • Title: RET fusion genes in Korean non-small cell lung cancer.
    Author: Yoo SS, Jin G, Jung HJ, Hong MJ, Choi JE, Jeon HS, Lee SY, Lim JO, Park JY.
    Journal: J Korean Med Sci; 2013 Oct; 28(10):1555-8. PubMed ID: 24133367.
    Abstract:
    Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
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