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  • Title: Activities of alkaline phosphatase in first trimester chorion biopsy tissue.
    Author: Maxwell DJ, Blau K, Johnson RD, Lilford RJ.
    Journal: Prenat Diagn; 1985; 5(4):283-6. PubMed ID: 2413434.
    Abstract:
    We have determined the activity of alkaline phosphatase in chorionic villous tissue obtained in the first trimester of pregnancy, in order to obtain the normal range of values as a prerequisite for application to the prenatal diagnosis of the rare bone disease hypophosphatasia. The activities found were a combination of intestinal and liver/bone/kidney types; traces of placental type were present in only one sample.
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