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  • Title: Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients.
    Author: Cabaleiro T, Román M, Gallo E, Ochoa D, Tudelilla F, Talegón M, Prieto-Pérez R, García-Díez A, Daudén E, Abad-Santos F.
    Journal: Eur J Dermatol; 2013; 23(5):640-5. PubMed ID: 24135300.
    Abstract:
    BACKGROUND & OBJECTIVES: Susceptibility to psoriasis has been associated with the HLA-C*0602 allele, although it may be affected by other polymorphisms. MATERIALS & METHODS: We genotyped 142 patients and 160 healthy volunteers to evaluate the possible relationship between susceptibility to psoriasis and the HLA-C*0602 allele and polymorphisms in the TNF, IL12B, and IL23R genes. RESULTS: The frequency of the wild-type TNF-238, TNF-308, and TNF-1031 genotypes was greater in patients with psoriasis than in healthy volunteers, although that of the mutant TNF-857 genotype was higher. The only difference between psoriasis and psoriatic arthritis was TNF-857. The frequency of the HLAC*0602 allele was higher in psoriatic patients than in healthy volunteers. No differences were observed for IL12B and IL23R. Multivariate logistic regression analysis only confirmed these associations for TNF-238, TNF-857, and HLA-C*0602. CONCLUSION: Our results support an association between susceptibility to psoriasis and TNF polymorphisms in the Spanish population.
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