These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Comparison of the haemodynamic effects in man of the beta-adrenergic blocking substances Kö 1366 and practolol (author's transl)].
    Author: Gloger K.
    Journal: Arzneimittelforschung; 1975 Aug; 25(8):1300-3. PubMed ID: 241365.
    Abstract:
    In 21 healthy male persons haemodynamic changes (heart rate, end-diastolic pulmonary artery pressure, training condition of heart, a so-called index of heart sufficiency and arterial blood pressure) at rest and during dynamic exercise were compared respectively before and after i.v. injection of 0.0375 mg/kg of the beta-adrenergic blocking drug K+5Ao 1366 [O-(2-hydroxy-3-(tert. butylamino)-propoxy)-benzonitril-hydrochloride], of 0.3 mg/kg practolol [4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide] and a placebo. According to the analysed parameters Kö 1366 has an essentially better beta-adrenergic blocking potency than practolol. Neither of the two substances has a negative inotropic effect or influences the arterial blood pressure.
    [Abstract] [Full Text] [Related] [New Search]