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  • Title: Meglumine: A novel and efficient catalyst for one-pot, three-component combinatorial synthesis of functionalized 2-amino-4H-pyrans.
    Author: Guo RY, An ZM, Mo LP, Wang RZ, Liu HX, Wang SX, Zhang ZH.
    Journal: ACS Comb Sci; 2013 Nov 11; 15(11):557-63. PubMed ID: 24138196.
    Abstract:
    An efficient one-pot synthesis of functionalized 2-amino-4H-pyrans by a meglumine-catalyzed three-component reaction has been developed. A broad range of substrates including aromatic and heteroaromatic aldehydes, isatin derivatives, and acenaphthenequinone are condensed with enolizable C-H activated compounds and alkylmalonates to give the desired products in high to excellent yields. This methodology provides an alternative approach for rapid access to construct a diversity-oriented library of 4H-pyrans.
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