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  • Title: Comparison between Gleason score and apparent diffusion coefficient obtained from diffusion-weighted imaging of prostate cancer patients.
    Author: Caivano R, Rabasco P, Lotumolo A, Cirillo P, D'Antuono F, Zandolino A, Villonio A, Macarini L, Salvatore M, Cammarota A.
    Journal: Cancer Invest; 2013 Nov; 31(9):625-9. PubMed ID: 24138289.
    Abstract:
    OBJECTIVES: To correlate the apparent diffusion coefficient (ADC) of prostate cancer patients with pathological Gleason scores (GS). METHODS: 40 patients with GS 2 + 3, 3 + 3, 3 + 4, or 4 + 4 were selected. The magnetic resonance imaging (MRI) study was performed adding axial diffusion-weighted imaging (DWI) sequences to the standard MRI protocol. ADC values obtained were correlated with the GS data. RESULTS: Statistically significant differences of ADC (p < .05) were found among GS groups with a trend of decreasing ADC values with increasing GS. CONCLUSIONS: The ADC values may help clinicians to delineate prostate carcinoma, recognizing its high- or low-grade compartments.
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