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  • Title: A novel synthesis of antiviral nucleoside phosphoramidate and thiophosphoramidate prodrugs via nucleoside H-phosphonamidates.
    Author: Sun Q, Li X, Gong S, Liu G, Shen L, Peng L.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2013; 32(11):617-38. PubMed ID: 24138500.
    Abstract:
    A novel and efficient method for the preparation of antiviral nucleoside 5'-H-phosphonamidates has been developed. The oxidization of the H-phosphonamidate intermediates with iodine and sulfur afforded nucleoside 5'-phosphoramidates and 5'-thiophosphoramidates in high yields.
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