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  • Title: Riboswitches in eubacteria sense the second messenger c-di-AMP.
    Author: Nelson JW, Sudarsan N, Furukawa K, Weinberg Z, Wang JX, Breaker RR.
    Journal: Nat Chem Biol; 2013 Dec; 9(12):834-9. PubMed ID: 24141192.
    Abstract:
    Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. However, the mechanisms by which c-di-AMP triggers these physiological responses have remained largely unknown. Notably, a candidate riboswitch class called ydaO associates with numerous genes involved in these same processes. Although a representative ydaO motif RNA recently was reported to weakly bind ATP, we report that numerous members of this noncoding RNA class selectively respond to c-di-AMP with subnanomolar affinity. Our findings resolve the mystery regarding the primary ligand for this extremely common riboswitch class and expose a major portion of the super-regulon of genes that are controlled by the widespread bacterial second messenger c-di-AMP.
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