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  • Title: The mechanism of myelopoiesis inhibition in childhood acute leukemia.
    Author: Vladimirskaya EB.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1985; 112(4):537-41. PubMed ID: 2414182.
    Abstract:
    The use of leukemic cells as source of CSF has been found to result in sharply reduced colony formation along with diminished proliferative activity of clonogenic precursors of nonleukemic granulo- and monocytopoiesis. Cells of a leukemic clone have no cytotoxic effect on the normal precursors of granulo- and monocytopoiesis and reduce the proliferative potential of these because their proliferation stimulating activity is low.
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