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  • Title: Mechanisms of napelline action stimulating the regeneration of hemopoietic tissue in cytostatic myelosuppression.
    Author: Zyuz'kov GN, Zhdanov VV, Udut EV, Miroshnichenko LA, Losev EA, Simanina EV, Chaikovskiy AV, Suslov NI, Povet'eva TN, Krapivin AV, Nesterova YV, Agafonov VI, Minakova MY, Stavrova LA, Danilets MG, Ligacheva AA, Trofimova ES, Ivanova AN, Goldberg VE, Reikchart DV, Dygai AM.
    Journal: Bull Exp Biol Med; 2013 Aug; 155(4):439-42. PubMed ID: 24143362.
    Abstract:
    Pronounced regenerative effects of alkaloid napelline extracted from Aconitum baicalense on granulocytic hemopoiesis were revealed in the model of cytostatic myelosuppression. Activation of functions of hemopoietic progenitor cells along with increased feeder capacity of the stromal elements in the hemopoiesis inducing microenvironment with decreased levels mesenchymal progenitor cells in the bone marrow are the mechanisms underlying the hemostimulating action of this substance.
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