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  • Title: Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus.
    Author: Sparks DL, Markesbery WR, Slevin JT.
    Journal: Neurobiol Aging; 1985; 6(3):213-7. PubMed ID: 2414677.
    Abstract:
    Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.
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