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  • Title: Four-component domino strategy for the combinatorial synthesis of novel 1,4-dihydropyrano[2,3-c]pyrazol-6-amines.
    Author: Kanchithalaivan S, Sivakumar S, Ranjith Kumar R, Elumalai P, Ahmed QN, Padala AK.
    Journal: ACS Comb Sci; 2013 Dec 09; 15(12):631-8. PubMed ID: 24147861.
    Abstract:
    An efficient one-pot four-component domino protocol for the combinatorial synthesis of novel 1,4-dihydropyrano[2,3-c]pyrazol-6-amines has been achieved. This transformation presumably occurs via cyclization-Knoevenagel condensation-Michael addition-tautomerism-intramolecular O-cyclization-elimination sequence of reactions. The significant features of this reaction include expedient one-pot process, short reaction time, no column chromatographic purification, excellent yield, and readily available starting materials.
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