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  • Title: Differential sensitivity of [3H]nitrendipine binding to cations of toxicological interest in various rat brain areas.
    Author: Rius RA, Govoni S, Battaini F, Trabucchi M.
    Journal: Toxicol Lett; 1985 Sep; 27(1-3):103-8. PubMed ID: 2414865.
    Abstract:
    [3H]Nitrendipine ([3H]NTP) is a radiolabelled calcium antagonist which can be used to study neuronal calcium (Ca2+) channels. The interaction of Mn2+, Zn2+, Pb2+ and La3+ on [3H]NTP binding was studied in 3 brain areas particularly rich in [3H]NTP binding sites. Differences were observed in the brain regional distribution of [3H]NTP binding as well as in their sensitivity to the metal ions Pb, Mn and Zn. The binding data suggest that neuronal Ca2+ channels in different brain areas display distinct sensitivity to selected divalent cations.
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