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  • Title: Interferon induction by viruses. XIII. Detection and assay of interferon induction-suppressing particles.
    Author: Marcus PI, Sekellick MJ.
    Journal: Virology; 1985 Apr 30; 142(2):411-5. PubMed ID: 2414906.
    Abstract:
    An assay is described for detecting and measuring the capacity of a single virus particle to suppress completely the yield of interferon from a cell otherwise competent to product interferon. The assay defines virus populations in terms of a newly quantifiable attribute--interferon induction-suppressing particles (ISP). The antagonistic actions of interferon-inducing particles and interferon induction-suppressing particles are thought to determine the interferon-inducing capacity intrinsic to a virus population.
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