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  • Title: The effect of crown ethers on ionic currents in myelinated nerve fibres from Xenopus laevis.
    Author: Kristbjarnarson H, Arhem P.
    Journal: Acta Physiol Scand; 1985 Mar; 123(3):261-8. PubMed ID: 2414973.
    Abstract:
    The effect of several crown ethers on the currents at the node of Ranvier was studied. At differing potencies they caused a time- and potential-dependent inactivation of potassium permeability and a time- and potential-independent decrease in sodium permeability. The relative effect on potassium and sodium systems varied and was not directly related to their ionophoric properties. A computer analysis indicated that the induced inactivation was dependent on the normal potassium activation mechanism.
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