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  • Title: [Substance P. New cyclic analogs].
    Author: Mutulis FK, Mutule IE, Maurops GKh, Sekatsis IP, Grigor'eva VD.
    Journal: Bioorg Khim; 1985 Sep; 11(9):1276-8. PubMed ID: 2415137.
    Abstract:
    [Adpoc-Glu(N3)6, (Met-N3)11] substance P-(6-11)-peptide was reacted with diamines H2N(CH2) nNH2 (n = 3-10, 12) to give cyclopeptides. Subsequent careful cleavage of the Adpoc group leads to the formation of compounds of type cyclo-[H-Glu-Phe-Phe-Gly-Leu-Met-NH-(CH2) n-NH-] X HCl. The substances produce a specific two-phase myotropic effect in experiments on isolated guinea pig ileum. The compounds where n is 3, 7, 12 exhibit also a hypotensive activity when assayed on anaesthetized rats.
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