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  • Title: Gamma glutamyl transpeptidase activity in rat urothelium treated with bladder carcinogens.
    Author: Ozono S, Homma Y, Oyasu R.
    Journal: Cancer Lett; 1985 Oct; 29(1):49-57. PubMed ID: 2415236.
    Abstract:
    Gamma glutamyl transpeptidase (GGT) activity during urothelial carcinogenesis was examined histochemically in rats treated with N-methyl-N-nitrosourea (MNU) or N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN). GGT-positive cells developed with a high frequency in foci of nodulopapillary hyperplasia and carcinoma. GGT-positive cells, both individually and in nests, were also frequent in foci of simple hyperplasia and interlesion normal urothelium of carcinogen-treated bladders. The results suggest that development of GGT-positive cells in interlesion normal urothelium is specific to carcinogen treatment.
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