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  • Title: Natalizumab-induced progressive multifocal leukoencephalopathy.
    Author: Thaker AA, Schmitt SE, Pollard JR, Dubroff JG.
    Journal: Clin Nucl Med; 2014 Jul; 39(7):e365-6. PubMed ID: 24152618.
    Abstract:
    A 55-year-old woman with known relapsing-remitting multiple sclerosis (RRMS) on natalizumab (Tysabri®) for 3 years was admitted to the hospital with worsening word-finding difficulties and gait instability. Neurologic examination revealed right hemianopia, right arm hemiplegia, right-sided sensory loss, and global aphasia. The patient underwent MRI and PET imaging with concurrent electroencephalogram. She was subsequently diagnosed with natalizumab-induced progressive multifocal leukoencephalopathy (PML) and treated with plasmapheresis, intravenous immunoglobulin, and high-dose intravenous steroids. Steroids were continued over a 3-month hospital course and tapered upon discharge. Speech, arm strength, and ambulation have since improved.
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