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  • Title: bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia.
    Author: Bartram CR.
    Journal: J Exp Med; 1985 Dec 01; 162(6):2175-9. PubMed ID: 2415665.
    Abstract:
    Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species. Participation of the c-abl oncogene in this genomic recombination could be ruled out by in situ hybridization studies and Northern blot analysis.
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