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  • Title: The relative translation efficiencies of reovirus messenger RNAs.
    Author: Gaillard RK, Joklik WK.
    Journal: Virology; 1985 Dec; 147(2):336-48. PubMed ID: 2416117.
    Abstract:
    The relative translation efficiencies of reovirus messenger RNAs were measured by infecting BHK cells with serotype 1, 2, or 3 virus and measuring the rate of formation of each viral protein species and the amount of each viral single-stranded (ss) RNA species present in the infected cells throughout the multiplication cycle. The translation efficiency of each ssRNA species was then calculated as a percentage of the species that was translated most efficiently. The relative translation efficiencies of the various ssRNA species did not change significantly during the multiplication cycle and cognate mRNA species of serotype 1, 2, and 3 virus were generally translated with similar efficiencies. However, the relative translation efficiencies of the individual ssRNA species differed greatly. The most efficiently translated ssRNA species was usually species s4, followed by species m2 which, on average, was translated about two-thirds as efficiently as species s4. Species s2 and s3 were translated slightly less than one-half as efficiently as species s4; species m3, l2, and l3 one-quarter to one-third as efficiently; and species s1 one-twentieth to one-tenth as efficiently. Finally, species l1 and m1 were translated very inefficiently under all conditions; their translation efficiencies were usually no more than 1% of that of species s4.
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