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  • Title: Intravenous gamma-globulin (Sandoglobulin) therapy in the management of four patients with immune thrombocytopenic purpura.
    Author: Blanchette VS.
    Journal: Vox Sang; 1985; 49 Suppl 1():32-41. PubMed ID: 2416125.
    Abstract:
    We have used intravenous polyvalent intact gamma-globulin concentrate (Sandoglobulin-immune globulin IV) in the management of 2 adults and 2 children with refractory immune thrombocytopenic purpura (ITP). Excellent responses were obtained in 2 children with chronic ITP as compared to no response in 2 adults with long-standing, severe ITP. The 2 adults who failed intravenous Sandoglobulin therapy had prolonged reticuloendothelial system (RES) clearance of autologous antibody-coated red blood cells before initiation of therapy as compared to normal RES clearance rates in the 2 children who responded to therapy. Blockade of the RES is one mechanism by which intravenous Sandoglobulin therapy may reverse thrombocytopenia in ITP - our observations suggest that patients who have impaired RES function before starting intravenous Sandoglobulin therapy may fail to respond to treatment. Continued studies are required to confirm these observations.
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