These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin.
    Author: Fjellner B, Hägermark O.
    Journal: Acta Derm Venereol; 1985; 65(5):409-12. PubMed ID: 2416164.
    Abstract:
    Cutaneous pruritic effects of synthetic platelet activating factor (PAF-acether) and, in particular, its interference with dermal mast cells, were studied in human volunteers. Intradermal injections of 10-100 ng produced dose-dependent flare and itching responses. The cutaneous reactions were inhibited by local administration of the H1 antihistamine mepyramin. The cutaneous responses were also markedly reduced in histamine-depleted skin. These findings indicate that the cutaneous responses produced by PAF-acether were mediated via an indirect and mainly histamine-dependent mechanism.
    [Abstract] [Full Text] [Related] [New Search]