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  • Title: Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression.
    Author: Han G, Zhao W, Wang L, Yue Z, Zhao R, Li Y, Zhou X, Hu X, Liu J.
    Journal: Brain Res; 2014 Jan 16; 1543():1-8. PubMed ID: 24161825.
    Abstract:
    Glioma stem-like cells have been demonstrated to have highly invasive activity, which is the major cause of glioma recurrence after therapy. Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored. In the current study, we aimed to explore the role of leptin during glioma stem-like cells invasion as well as the signaling pathway. We found that glioma stem-like cells exhibited high invasive potential, especially in the presence of leptin, Ob-R coexpressed with CD133 in glioma stem-like cells was showed to be responsible for leptin mediated invasion of glioma stem-like cells. Our results indicated that leptin served as a key intermediary linking the accumulation of excess adipokine to the invasion of glioma stem-like cells, which may be a novel therapeutic target for suppressing tumor invasion and recurrence.
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