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  • Title: [Inhibition of histamine liberation with atropine sulfate following administration of d-tubocurarine].
    Author: Kubo K.
    Journal: Anaesthesist; 1985 Oct; 34(10):502-7. PubMed ID: 2416236.
    Abstract:
    The influence of atropine on the release of histamine following the administration of tubocurarine (Amelizol) was studied in anesthetized monkeys. Four groups were prepared: group (a) was not given atropine sulfate as a premedication and (b), (c) and (d) were given atropine 0.0125 mg/kg, 0.025 mg/kg, 0.05 mg/kg by intramuscular injection 30 min before the first blood sampling, respectively. Tubocurarine was given in a dose 0.5 mg/kg intravenously, to all animals. Blood samples were obtained in cases of the preinjection (control) and 1, 3, 6, 10 and 20 min after injection of tubocurarine. The concentration of histamine in the plasma was measured by a fluorometric method and high speed liquid chromatography. When atropine sulfate was given in doses over 0.025 mg/kg intramuscularly 30 min before the administration of tubocurarine, the release of histamine induced by tubocurarine was inhibited, compared to the findings in the non-pretreated groups. Atropine sulfate probably inhibits histamine release induced by tubocurarine through the mediation of intracellular cyclic GMP and atropine can be used as a premedicant in cases of general anaesthesia.
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