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  • Title: Sertoli-Leydig cell tumor of the ovary with alpha-fetoprotein production.
    Author: Tetu B, Ordóñez NG, Silva EG.
    Journal: Arch Pathol Lab Med; 1986 Jan; 110(1):65-8. PubMed ID: 2416299.
    Abstract:
    A case of poorly differentiated Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein (AFP) levels occurred in a 17-year-old girl. No germ cell component and no heterologous elements were identified, but a retiform pattern was present. Immunohistochemical studies demonstrated immunoreactivity for AFP and testosterone in Leydig's cells only. Secretion of AFP by Sertoli-Leydig cell tumors has rarely been mentioned previously, and its mechanism is difficult to explain. Non-germ cell tumors must be considered in the differential diagnosis of ovarian tumors with elevated serum AFP levels.
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