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  • Title: The subunit structure of the insulin receptor and molecular interactions with major histocompatibility complex antigens.
    Author: Fehlmann M, Chvatchko Y, Brandenburg D, Van Obberghen E, Brossette N.
    Journal: Biochimie; 1985; 67(10-11):1155-9. PubMed ID: 2416352.
    Abstract:
    Insulin receptors were labeled with 125I-photoreactive insulin (specifically labeling alpha-subunits) and by insulin-stimulated autophosphorylation (specifically labeling beta-subunits). The results show that the insulin receptor exists under different free and disulfide-linked combinations of alpha and beta subunits. Moreover, the insulin receptor is closely associated to class I antigens of the major histocompatibility complex to form a high molecular weight multi-molecular membrane complex.
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