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  • Title: [High blood triiodothyronine and the euthyroid state].
    Author: Brisson-Lougarre A, Abbal M, Hoff M, Blum CJ.
    Journal: C R Acad Sci III; 1985; 301(16):727-30. PubMed ID: 2416407.
    Abstract:
    A high excess of circulating T3 was observed in an euthyroid woman. Agarose gel electrophoresis of serum preincubated with 125I-T3 revealed an abnormal T3-binding in gamma-globulin zone. This binding interfered with the hormone radioimmunoassay. Immunological characterization identified this protein as an IgG-K and IgG-lambda polyclonal antibody that bound T3 but not T4. Scatchard analysis of 125I-T3 binding to the gamma-globulin fraction isolated showed a single class of binding sites with a high affinity Ka = 0.4 X 10(9) L/M and maximal binding capacity of 5.2 X 10(-9) M.
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