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  • Title: Successful lung transplantation in a case with diffuse pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia.
    Author: Fukushima H, Mitsuhashi T, Oto T, Sano Y, Kusano KF, Goto K, Okazaki M, Date H, Kojima Y, Yamagishi H, Takahashi T.
    Journal: Am J Transplant; 2013 Dec; 13(12):3278-81. PubMed ID: 24165284.
    Abstract:
    Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT.
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