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  • Title: Studies on monovalent anaphylactogens with carbohydrate auxiliary groups: exclusion of an artefact.
    Author: Guenin R, Schneider CH.
    Journal: Int Arch Allergy Appl Immunol; 1986; 79(1):49-52. PubMed ID: 2416697.
    Abstract:
    N1-DNCP-N6-lactobionoyl-1,6-hexanediamine is an elicitor of anaphylactic reactions in the guinea pig passively sensitized by antisera raised with a DNCP-bovine gammaglobulin conjugate. If the antisera contained anticarbohydrate antibodies against the carbohydrate residues of the globulin, significantly cross-reacting with the lactobionoyl moiety, anaphylactogenic cell triggering would be by classical hetero-specific bridging which involved the DNCP- and the lactobionoyl residues as ligands. This possibility was excluded by showing that a bis-lactobionoyl conjugate is unable to elicit anaphylactic reactions.
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