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  • Title: Combined polychemotherapy and radiotherapy in advanced inoperable squamous cell carcinoma of the head and neck.
    Author: Rosso R, Merlano M, Scarpati D, Grimaldi A, Bonelli L, Barbieri A.
    Journal: Head Neck Surg; 1985; 8(2):74-7. PubMed ID: 2416710.
    Abstract:
    Between August 1979 and August 1984, 46 untreated, inoperable patients with advanced squamous cell carcinoma of the head and neck were submitted to a combined modality of treatment based on four courses of polychemotherapy (vincristine, bleomycin, and methotrexate), rotated with three courses of radiotherapy, 20 Gy each. Forty-six patients entered the study: 45 were evaluable for their response to the treatment and 46 for toxicity effects. We observed 26 complete responses (57.7%) and 14 partial responses (31.1%); overall actuarial survival was 28% at 55 months. Mucositis occurred in 11 patients, 3 patients suffered from nausea and vomiting, 2 patients developed fever, and 1 had a platelet count of 50,000/mm3. One toxic death occurred: one patient developed an acute renal failure related to Methotrexate.
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