These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Influence of substance P on nociception and stress.
    Author: Oehme P, Hilse H, Görne RC, Hecht K.
    Journal: Pharmazie; 1985 Aug; 40(8):568-70. PubMed ID: 2417265.
    Abstract:
    In 1980 Oehme and co-workers [11] reported that Substance P (SP) has a dual effect on nociception, which is related to the pain threshold before SP administration. Our recent results showed that the N-terminal part of the SP sequence may be important to the hyperalgesic action, and the C-terminal part to the analgesic action of this peptide. The hyperalgesic effect of SP (and N-terminal fragments of SP) seems to be related to the "anti-stress" effect which was first demonstrated by Hecht and co-workers [5] and Oehme and co-workers [12]. Interaction of SP with opioid peptides could be the common reason of both the "anti-stress" effect and the hyperalgesic activity of SP.
    [Abstract] [Full Text] [Related] [New Search]