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  • Title: Endoscopic treatment of bronchus stump fistulae following pneumonectomy with fibrin sealant in domestic pigs.
    Author: Waclawiczek HW, Chmelizek F.
    Journal: Thorac Cardiovasc Surg; 1985 Dec; 33(6):344-6. PubMed ID: 2417369.
    Abstract:
    Occlusion of the transected bronchus after pneumonectomy was achieved by transthoracic fibrin sealing in 14 domestic pigs. In 9 additional animals standardized bronchus stump fistulae could also be closed with fibrin sealant which was applied through a flexible bronchoscope. An average of 1 ml of fibrin sealant containing 500 units of thrombin and 3500 units of Aprotinin was necessary to achieve bronchial closure and to prevent early dissolution of the sealant. Endoscopic closure of a bronchus fistula by fibrin plug was successfully employed in one clinical case.
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